Beyond purely structural studies, it has been recognized early on that correlated mutations encode multiple conformations thus paving the way to investigate evolutionary-conserved conformational dynamics. How can we combine DCA with enhanced sampling strategies for determining conformational ensembles? The project will also develop processes and prototypes of high-value products of blackcurrants and sour cherries, which can sharpen the competitive edge for Danish berry growers and industry. Last but not least, co-evolutionary techniques offer an unprecedented opportunity to use the inferred statistical models for bioengineering purposes, by generating sequences that are optimized for some design requirements while respecting all the pairwise statistical couplings imposed by evolution. Proteins 18 4 PLoS Comput Biol. Outstanding open questions include:.
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Women Paving The Way In The Construction Industry. by DCAStaffWriter • December 5, Women have traditionally played a small role in the construction. Paving the Way to a New Career in Construction DCA Headquarters Address: W. Renner Road, Suite Richardson, TX Scientists are paving the way for more sustainable Danish berry production.
Blackcurrants Using the berries for wine, vinegar and juice instead could be one way of solving the problem. The Danish DCA, Food. Related.
The combination of the co-evolutionary information with molecular modeling techniques has already allowed the accurate determination of high-resolution protein structures [3,4], even for experimentally challenging targets[5,6], and it can be extended to other biomolecules, such as RNA.
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Blackcurrants, sour cherries and other delicious and healthy Danish berries can become novel ingredients in specialist food products such as wine, vinegar and juice.
Nucleic Acids Res. Enhancing the prediction of membrane protein topology, structures and associations using co-evolutionary information. Stock photo.
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Sour cherries and blackcurrants are not the only types of berry included in the project. Stock photo. This is to be achieved by more rational management practices and by increasing the added value of the final product. Enhancing the prediction of membrane protein topology, structures and associations using co-evolutionary information.
Coevolutionary methods for the prediction and design of protein structure and interactions – CECAM
This is one of the methods used in a new project led by Aarhus University to increase the sustainability of the Danish berry production.
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This is where cherry wine made on sour cherries, fruit wine vinegars and gourmet juices — or other novel products — enter the picture.
Nucleic Acids Res. Towards an atlas of conformational movements. PNAS 1 Furthermore, protein-protein interactions represent an exciting application of DCA where the simultaneous problem of predicting the interaction partners alongside the structure of the complexes pose a fascinating challenge[11,12].
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|The project works with berry production from different angles — both in the field and at the processing stage.
Particularly, the analysis of correlated mutations has attracted an ever-increasing popularity in the last decade and it is currently one of the most promising tool in structural and computational biology.
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Co-evolutionary methods for the prediction and design of protein structure and interactions. The production of Danish berries for processing is under pressure due to fierce competition from abroad.
Nucleic Acids Res. Following the CECAM guidelines we tried to optimize the structure of the workshop for maximizing the time devoted to scientific discussion and to foster exchange between researchers belonging to diverse scientific communities.
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